Baclofe Granules

Baclofe GranulesBaclofen (brand names Kemstro, Lioresal, and Gablofen) is a derivative of gamma-aminobutyric acid (GABA). It is primarily used to treat spasticity and is under investigation for the treatment of alcoholism.

It is an agonist for the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups, and has been shown to prevent rises in body temperature induced by the drug MDMA in rats.

In addition, research has shown baclofen to be effective in the treatment of alcohol dependenceand withdrawal, by inhibiting both withdrawal symptoms and cravings.

A very beneficial property of baclofen is that tolerance does not seem to occur to any significant degree — baclofen retains its therapeutic anti-spasmodic effects even after many years of continued use.

However, oral dosage must be carefully regulated; significantly high doses of the drug, particularly 80 milligrams per day or higher, can cause excessive drowsiness that can interfere with daily function.

Available Form:
Baclofe Granules
Baclofe Pellets

Umang Pharmatech equipments used for production of Baclofe Granules:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Baclofe Granules
Systematic (IUPAC) Name
Baclofe Granules
Identifiers
Baclofe Granules
Chemical data
(RS)-4-amino-3-(4-chlorophenyl)butanoic acid
CAS number : 1134-47-0
ATC code : M03BX01
PubChem : CID 2284
IUPHAR ligand : 1084
DrugBank : APRD00551
ChemSpider : 2197
UNII : H789N3FKE8
KEGG : D00241
ChEMBL : CHEMBL701
Formula : C10H12ClNO2
Mol. mass : 213.661 g/mol


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